Explore sparse factors derived from GDSC cell lines
Pre-defined filters
Colon Cancer Network
Shared Network between Mesothelioma and Kindey
Afatinib (BIBW2992) Response Network
Camptothecin and SN-38 Network
Cis-effect (CN(+) and GE(+))
Cis-effect (MT and GE(-))
Custom
Filters
Factor Filters
Gene
Gene(s) to focus
How to filter factor?
Relative factor loading
OR
Cell line
Cell line(s) to focus
How to filter factors?
Relative factor loading
OR
Data type
Primary data type
Any
Gene expression (+)
Gene expression (-)
Mutation
Copy number (+)
Copy number (-)
Secondary data type
Any
Gene expression (+)
Gene expression (-)
Mutation
Copy number (+)
Copy number (-)
Relative factor loading
Tissue type/drug Filters
Tissue type
Tissue type classification
General
Specific
Both
Minumum number of cell lines
FDR
Tissue type(s) to focus
How to filter factors/tissues?
OR
All tissues
Drug
Minimum prediction performance
EN coefficient
Drug(s) to focus
How to filter factors/drugs?
OR
All drugs
Pathway Filters
Hallmark
Include Hallmark
FDR
Top
KEGG Pathway
Include KEGG
FDR
Top
GOBP
Include BP
FDR
Top
Network Visualization
Individual factor analysis
Factor selection
Number of top genes
Number of top cell lines
Table visualization of factors
Pathway enrichment anlaysis
Tissue type enrichment analysis
Association to drug responses
Gene factor
Cell line factor
General Classification
Specific Classification